Quorum Sensing Orchestrates Antibiotic Drug Resistance, Biofilm Formation, and Motility in Escherichia coli and Quorum Quenching Activities of Plant-derived Natural Products: A Review

Quorum sensing (QS) is a type of cell-to-cell communication that influenced by an increase in signaling molecules known as autoinducers, which correlated to the density microbial communities. In this review, we aim discuss and provide updates on different used Escherichia coli, such acyl-homoserine lactone (AHL), autoinducer-2 (AI-2), indole influence key phenotypes antibiotic drug resistance, biofilm formation, motility during quorum sensing. Based literature, E. coli have functions AHL was found cause modulation resistance inhibition formation motility. Meanwhile, AI-2 modulate On other hand, existing various plants possess phytochemicals can be alter QS its downstream swimming swarming motility, genes related curli production. However, exact physiological molecular mechanisms these natural compounds are still understudied. Understanding those therefore highly recommended conduct necessary step for future scholars develop drugs target actions QS-signaling receptors linked without putting bacteria under stress, thereby preventing development resistance.